AOD 9604 10MG

AOD-9604 5 mg — hGH Fragment Analog for Metabolic Research

AOD-9604 is a synthetic peptide analog based on the C-terminal fragment (residues 176–191) of human growth hormone (hGH), with additional substitutions designed to stabilize the sequence. In preclinical and exploratory clinical research, AOD-9604 has been investigated for its effects on adipocyte metabolism, lipolytic signaling, and energy-balance markers, with an emphasis on fat-mass–related endpoints rather than classical hGH growth effects.

What It Is

• Class: hGH fragment analog (176–191–derived sequence)
• Concept: Retains regions of hGH thought to influence lipolysis and anti-lipogenesis, while lacking domains associated with growth-promoting and hyperglycemic actions in standard models.
• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Adipocyte Metabolism

• Explored for stimulation of lipolysis (breakdown of stored triglycerides)
  in adipocytes in vitro.
• Investigated for anti-lipogenic actions (reduced lipid accumulation) in
  diet-induced obesity models.
• Studies suggest activity that is ?-adrenergic–independent, differentiating it from classical catecholamine-driven lipolysis.

Systemic & Metabolic Endpoints

• Animal studies have evaluated changes in fat-mass distribution and
  body-weight trajectories under high-calorie feeding.
• Exploratory human datasets have examined safety, tolerability, and effects on obesity-related measures in selected cohorts.
• Ongoing research interest in glucose and lipid markers, inflammatory indices, and overall metabolic profile modulation.

Selected Research Highlights

• Obesity Models: AOD-9604 has been tested in rodent models of diet-induced obesity for effects on body fat, weight gain, and adipose-tissue histology.
• Human Studies: Early-phase clinical work has primarily focused on safety and tolerability, with exploratory analysis of weight-related and metabolic endpoints.
• Mechanistic Distinction: Compared with full-length hGH, fragment-based analogs such as AOD-9604 are studied for the potential to isolate fat-metabolism pathways from broader growth and glucose effects.

Chemical & Handling Information

• Type: Synthetic peptide, hGH fragment analog
• Peptide length: Short peptide derived from hGH(176–191) with stabilizing substitutions
• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: AOD-9604
• Amount: 5 mg per vial
• Form: Lyophilized powder
• Purity: ?99% (HPLC); COA per lot available
• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• For extended stability, refrigeration or freezing of the lyophilized peptide is recommended per laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term use.
• For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.