GHK 100mg

GHK-Cu 100 mg — Copper Tripeptide Complex for Regenerative Research

GHK-Cu is a copper(II) complex of the endogenous tripeptide glycyl-L-histidyl-L-lysine (GHK). It has been studied in preclinical and exploratory clinical settings for roles in wound repair, skin regeneration, hair biology, and extracellular-matrix (ECM) remodeling. GHK-Cu is of interest as a signaling molecule that can influence growth factors, inflammatory mediators, and matrix-metaloproteinase (MMP) balance in various tissue models.

What It Is

• Class: Endogenous tripeptide–copper complex
• Peptide sequence: Gly-His-Lys (GHK) chelating Cu²⁺
• Concept: Naturally occurring low–molecular weight peptide found in plasma and tissues, studied as a regulator of repair and remodeling processes when complexed with copper.

Proposed Mechanisms (Preclinical)

ECM & Tissue Remodeling

• Explored for stimulation of collagen, elastin, and glycosaminoglycan synthesis in fibroblast and skin models.
• Modulation of MMP/TIMP balance (matrix metalloproteinases and tissue inhibitors of metalloproteinases) associated with ECM turnover.
• Support of wound closure, granulation-tissue quality, and tensile strength in animal injury models.

Inflammation, Oxidative Stress & Hair Biology

• Investigated for anti-inflammatory and antioxidant-linked effects, including changes in cytokine and reactive-oxygen–species markers.
• Preclinical and cosmetic research on hair-follicle signaling,
  anagen/follicle-support markers, and scalp–skin parameters.
• Model-dependent changes in angiogenesis and microcirculation in skin and subcutaneous tissues.

Selected Research Highlights

• Skin Regeneration: GHK-Cu has been studied in creams, solutions, and injectable formats (research/clinical) for effects on wrinkles, elasticity, and overall skin appearance, often compared with retinoids or other actives.
• Wound-Healing Models: Animal and in vitro work suggests improvements in wound contracture, epithelialization, and ECM organization vs. controls.
• Hair & Scalp: Investigations have examined changes in hair density, shaft thickness, and scalp quality when GHK-Cu is incorporated into topical formulations.
• Systemic Markers: Experimental studies have explored impacts on
  oxidative-stress markers, inflammatory mediators, and gene-expression panels related to repair and aging.

Chemical & Handling Information

• Type: Copper(II) tripeptide complex (GHK-Cu)
• Peptide length: 3 amino acids (glycyl-L-histidyl-L-lysine)
• Appearance: Blue to blue-green lyophilized powder (color may vary by lot due to copper content and excipients)

Specifications

• Glow Pura: GHK-Cu
• Amount: 100 mg per vial
• Form: Lyophilized powder
• Purity: ?99% (HPLC); COA per lot available
• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability, according to laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term use.
• For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.