Snap 8

SNAP-8 10 mg — Acetyl Octapeptide-3 for Neuromodulatory & Cosmetic Peptide Research

SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide described as a neuromodulating peptide that mimics the N-terminal end of SNAP-25, a key protein involved in the SNARE complex required for synaptic vesicle fusion. In cosmetic and preclinical research, SNAP-8 has been investigated as a topical peptide targeting expression-line and wrinkle-related endpoints.

What It Is

• Class: Synthetic octapeptide (Acetyl Octapeptide-3)
• Concept: Designed as an extended analog of Argireline®-type peptides to interact with SNARE-complex–related pathways.
• Research focus: Neuromodulatory effects at the level of vesicle fusion/exocytosis and cosmetic skin-appearance endpoints.

Proposed Mechanisms (Preclinical/Ex Vivo)

SNARE Complex Interaction

• Modeled on the N-terminal region of SNAP-25, a component of the SNARE complex involved in synaptic vesicle fusion.
• In vitro and ex vivo cosmetic research explores interference with neurotransmitter release at the neuromuscular junction.
• Conceptually aimed at reducing repetitive expression-related muscle contraction in superficial facial regions.

Cosmetic & Skin-Related Endpoints

• Frequently evaluated in topical formulations for visible changes in the appearance of fine lines and wrinkles.
• Studies focus on periorbital and forehead regions as common expression line areas.
• Research interest in combining SNAP-8 with other cosmetic peptides, humectants, and barrier-support actives.

Selected Research/Use Context

• In Vitro & Ex Vivo Models: Tested on cell and skin models for effects on neurotransmitter release, muscle-contraction surrogates, and surface appearance.
• Cosmetic Formulation Research: Widely used as a reference peptide in the development of anti-wrinkle and “expression-line” cosmetic products.

Chemical & Handling Information

• Type: Synthetic octapeptide (Acetyl Octapeptide-3)
• Peptide length: 8 amino acids
• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: SNAP-8 (Acetyl Octapeptide-3)
• Amount: 10 mg per vial
• Form: Lyophilized powder
• Purity: ?99% (HPLC); COA per lot available
• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability, according to laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term use.
• For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.